Cardiovascular effects of hypertonic solution NaCl 7.5% infusion depended on administration duration

Hypertonic solutions have been widely used for several years for the treatment of hypovolemia, in the context of small volume resuscitation. The aim of the present study was to investigate the possible impact of total infusion time of NaCl 7.5% on its efficacy in normovolemic patients. Continue reading →

Category: 2024, 2024b, Clinical Studies, Current issue
Keywords: Fluid therapy, Hypertonic Saline (7.5%), hypertonic solutions, Volume Expander
Authors (a/b order): Amaniti A., Apostolopoulou A., Fyntanidou B., Grosomanidis V., Kotzampassi K., Kyparissa M., Ourailoglou V., Palaska E.

Pyridostigmine induced cardiac arrest after anesthesia induction in a patient with Myasthenia Gravis

Myasthenia Gravis (MG) is an autoimmune disorder affecting the neuromuscular junction function and causing muscle weakness that gets worse during the day and after physical activity. The most common medication prescribed for MG treatment is pyridostigmine. Continue reading →

Category: 2024, 2024a, Case Reports
Keywords: Myasthenia Gravis, Pyridostigmine induced bradycardia, Pyridostigmine induced cardiac arrest
Authors (a/b order): Aggou M., Foroulis Ch., Fyntanidou B., Grosomanidis V., Kotzampassi K., Kyparissa M., Palaska E., Tsagkaropoulos S.

Prehospital Management Of Near Fatal Anaphylaxis

Anaphylaxis is a severe, potential life threatening allergic reaction, which is characterized by rapid onset and varied clinical manifestations involving in most of the cases the respiratory and cardiovascular systems and sometimes skin and mucosa. Twentysix patients (16♀ & 10♂) with a mean age of 59.7± 8.6yrs were included in this study. Continue reading →

Category: 2023, 2023b, Observational Articles
Keywords: Adrenaline, Allergy, Anaphylaxis, Antihistamine, Corticosteroids
Authors (a/b order): Amaniti A., Chatsiou E., Fortounis Κ., Fyntanidou B., Grosomanidis V., Kotzampassi K., Ourailoglou V., Papadopoulos A.

The work of breathing during mechanical ventilation in a porcine model of abdominal hypertension: The impact of sepsis

The work of breathing (WOB) is the amount of energy, which is consumed by the respiratory muscles, in order to perform one complete respiratory cycle. In several medical conditions, WOB might rise to a critical level which could necessitate initiation of mechanical ventilation (MV) or complicate weaning of the patient from MV. Continue reading →

Category: 2023, 2023a, Experimental Article
Keywords: abdominal compartment syndrome, abdominal hypertension, Work of Breathing
Authors (a/b order): Amaniti A., Deligianni M., Fyntanidou B., Gkarmiri S., Grosomanidis V., Kotzampassi K., Kyparissa M., Palaska E.

Hypertonic Saline Resuscitation in acute intraoperative hemorrhage:Case Series presentation

Four patients (♂/♀: 1/3), aged 51, 52, 50 and 58 years old, who underwent general surgery procedures, suffered acute major blood loss intraoperatively. For the management of acute hemorrhage, 4ml/kg NaCl 7.5% were administered in each patient at the fastest possible rate through the existing intravenous line. Both standard monitoring and Oesophageal Doppler Monitoring (ODM) were applied and heart rate (HR), mean arterial pressure (BPmean), stroke volume (SV), peak velocity (PV), mean acceleration (MA) and corrected flow time (FTc) were recorded at six different phases, before blood loss (Phase 1), before and after completion of NaCl 7.5% administration (Phases 2 & 3), 10min and 20min after NaCl 7.5% administration (Phases 4 and 5) and at the end of the surgical procedure (Phase 6). Continue reading →

Category: 2022, 2022b, Case Reports
Keywords: acute blood loss, Hypertonic saline solutions, Oesophageal Doppler Monitoring
Authors (a/b order): Deligianni M., Fortounis K., Fyntanidou B., Gkarmiri S., Grosomanidis V., Kotzampassi K., Kyparissa M., Ourailoglou V.

Intraoperative Hypoxemia in Thoracic Surgery: Impact on early outcome

Anesthesia for thoracic surgery presents specific challenges since anesthesiologists have to manage patients with several comorbidities, apply One Lung Ventilation (OLV) to facilitate surgery and at the same time they should try to maintain adequate safe oxygen levels. Hypoxemia is a common consequence of OLV. The aim of the present retrospective study was to investigate the impact of intraoperative hypoxia on the early outcome of patients. Continue reading →

Category: 2022, 2022a, Clinical Studies
Keywords: hypoxemia, One Lung Ventilation, Thoracic Anesthesia
Authors (a/b order): Alexiou I., Deligianni M., Foroulis Ch., Fyntanidou B., Grosomanidis V., Kioumis I., Kotzampassi K., Tsagkaropoulos S.

Respiratory mechanics in a porcine model of abdominal hypertension with or without sepsis

Increased Intraabdominal Pressure (IAP) is common in critical care patients and has detrimental effects on organs and systems. Several mechanisms and causes are involved in its pathogenesis. The aim of the present study was to investigate and record IAP effects alone and in combination with sepsis on respiratory mechanics. Continue reading →

Category: 2021, 2021d, Experimental Article
Keywords: abdominal compartment syndrome, abdominal hypertension, Mechanics of Respiratory system
Authors (a/b order): Fyntanidou B., Gkarmiri S., Grosomanidis V., Kazakos G., Kotzampassi K., Kyparissa M., Pertsikapa M., Theodosiadis P.

Επίδραση του υπέρτονου διαλύματος 7,5% στο Kαρδιαγγειακό Σύστημα

Η περιεγχειρητική χορήγηση υγρών αποτελεί τον ακρογωνιαίο λίθο στη διαχείριση των χειρουργικών ασθενών, αλλά και σημείο έντονων επιστημονικών αντιπαραθέσεων και διχογνωμιών για το είδος και την ποσότητα των χορηγούμενων διαλυμάτων^3,4. Οι χειρουργικοί ασθενείς κατά την περιεγχειρητική περίοδο, χρειάζονται υγρά, και μερικές φορές απαιτούνται μεγάλες ποσότητες για τη διατήρηση του ενδαγγειακού όγκου και της αιμοδυναμικής σταθερότητας. Ο περιορισμός στη χορήγηση υγρών αλλά και η υπερχορήγηση μπορεί να δημιουργήσουν προβλήματα ικανά να επηρεάσουν την έκβαση^5,6. Continue reading →

Category: 2021, 2021c, Clinical Studies
Keywords: fluids therapy, Hypertonic saline, hypertonic solutions, intravenous fluid
Authors (a/b order): Amaniti A., Chatsiou E., Fengoudaki M., Fyntanidou B., Grosomanidis V., Karagkouni D., Ourailoglou V., Theodosiadis E.

ΣΥΓΚΡΙΣΗ ΔΥΟ ΔΙΑΦΟΡΕΤΙΚΩΝ ΤΕΧΝΙΚΩΝ ΑΝΤΙΜΕΤΩΠΙΣΗΣ ΤΩΝ ΔΙΑΤΑΡΑΧΩΝ ΟΞΥΓΟΝΩΣΗΣ ΣΕ ΚΑΡΔΙΟΧΕΙΡΟΥΡΓΙΚΕΣ ΕΠΕΜΒΑΣΕΙΣ ΜΕ ΕΞΩΣΩΜΑΤΙΚΗ ΚΥΚΛΟΦΟΡΙΑ

Several prevention and treatment strategies have been applied in order to prevent hypoxemia after open heart surgery with comparable good results. The aim of this study is to compare the effectiveness of two different alveolar recruitment maneuvers [RM] for the management of oxygenation impairment in cardiac surgical patients. A total number of sixty patients were included in this study. All patients underwent cardiac surgical procedures with extracorporeal circulation and developed oxygenation impairment after withdrawal of extracirculation support and sternal closure. Patients were randomly assigned into two Groups A and B according to the applied RM. In Group A three hyperinflations of the lungs were applied at an airway pressure of 40cmH₂O for 10 sec, whereas in Group B Pressure Control Ventilation was applied for 2min with the inspiratory pressure set at 40cmH₂O. After application of any of the two RM, PEEP was increased from 5 to 10 cmH₂O in all patients. Anesthesia induction and maintenance and mechanical ventilation settings were similar in both study Groups. Continue reading →

Category: 2021, 2021a, Clinical Studies
Keywords: alveolar recruitment manoeuvre, atelectasis, cardiac surgery, hypoxemia
Authors (a/b order): Alexiou Ι., Antonitsis P., Fyntanidou B., Grosomanidis V., Kyparissa M., Papanikolaou D., Serchan P., Tsaousi G.

Tension pneumothorax, a reversible cause of cardiac arrest.

Pneumothorax is a collection of air in the pleural space between the lungs and the chest wall and depending on its cause it could be either spontaneous or traumatic. Tension Pneumothorax (TPT) can be a cause of cardiac arrest (CA) or might be a complication after chest compressions. According to the 2015 European Resuscitation Council guidelines on resuscitation, TP is considered one of the reversible causes of CA, which should be recognized and treated during cardiopulmonary resuscitation (CPR) Continue reading →