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Acute inflammatory response is the body’s direct response to noxious stimuli or to tissue necrosis. Ischemia-reperfusion lesion is a clinical state of acute inflammation with leucocyte-induced tissue damage. Ischemia promotes an inflammatory response which sensitizes tissues to further damage during reperfusion. Reperfusion activates inflammatory mediators from remote vascular or tissue sites or from the local vascular bed. Reperfusion remains the cornerstone for the repair of ischemic areas.

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NSAIDs are widely used compounds in the management of several acute and chronic pain syndromes. NSAIDs induce their action by blocking the cyclooxygenase enzymes, cox-1 and cox-2, during the conversion of arachidonic acid to prostaglandins. Conventional NSAIDs inhibit both cox isoforms and are therefore at risk of serious complications as gastrointestinal irritation, postoperative bleeding, renal failure, water and sodium retention and hepatic failure.

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