Transfusion related acute lung injury (TRALI), first described as a clinical entity in 1983, is characterized by acute non cardiogenic pulmonary oedema with hypoxia occurring within few hours of receiving blood products. It accounts for 1:5000 of all known transfusion reactions and is one of the leading causes of transfusion related death, approximately 5%. TRALI is thought to be underrecognised and under-reported. Suspected cases should be reported to the blood bank so any other products from the particular donor may be quarantined.
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