neuropathic pain

Since its identification as the active metabolite of nitroglycerin identical to endothelium derived relaxing factor, in mid-eighties, nitric oxide has been found over-all distributed in all body tissues implicated in many normal functions as well as pathophysiologic states, so that it has been aptly called biological jack-ofall- trades.

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Gabapentin was tested as complementary analgesic in 25 cancer patients in whom pain was not sufficiently controlled by transdermal fentanyl. Neuropathic pain syndrome in these patients consisted of burning pain and allodynia. Gabapentin was administered at a dose of 648±206,4mg, while dosage of transdermal fentanyl was fixed (261±98,1μg/h).

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