Shock represents an acute, life-threatening condition characterized by inadequate tissue perfusion and oxygenation, ultimately leading to multi-organ failure. Timely and targeted restoration of intravascular volume through fluid resuscitation remains a cornerstone of initial management. However, the traditional strategy of aggressive fluid administration has come under scrutiny in recent years, due to the risks associated with fluid overload and its related complications. Continue reading
Alport syndrome (AS) is a rare hereditary disease, in which there is a defect in type IV collagen, an essential constituent of basal membrane in kidney, ear and eye. This can cause progressive renal damage and eventually renal failure, as well as hearing loss and visual impairment. Definitive treatment, when end stage renal disease (ESRD) has ensued, is renal transplantation. Continue reading
