The aim of this study was to compare the combination of oral tramadol and midazolam to oral midazolam alone, in children undergoing adenotonsillectomy, as an oral premedication, regarding also sedation and postoperative pain relief. Sixty children selected for elective adenotonsillectomy were enrolled in this randomized, controlled prospective study. Patients were randomly allocated into two groups. Group M (n=30) received 0.5 mg.kg-1 oral midazolam and group MT (n=30) received 0.2 mg.kg-1 oral midazolam with 1 mg.kg-1 oral tramadol as a premedication 30min preoperatively. Standard general anesthesia technique was used.

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The study compares the efficacy of postoperative analgesia after the intravenous administration of opioids (nalbuphine, tramadol or morphine) in combination with ketamine in patients undergoing radical prostatectomy.Eighty eight patients scheduled for radical prostatectomy were randomly assigned in three groups. In Group A (n=31) Morphine was administered {bolus dose (BD) 0.05mg/Kg and continuous infusion (CI) at a dose [mg/24h =18-(agex0.15)]}, in Group B (n=28) Nalbuphine (BD 0.2mg/kg and CI at a rate 0.05mg/kg/h) and in Group C (n=29) Tramadol (BD 1.5mg/Kg and CI at a rate 0.15mg/Kg/h).

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Aiming the investigation of potential differences in accuracy of the algorithms of pediatric anesthesia in everyday practice, 338 children where studied, from newborns to 14 years old, who underwent scheduled or emergency operations in a 3 months period. They were divided according to their age into 4 groups (38 newborns and infants, 43 children from 1 to 3 years old, 90 children from 3 to 6 years old, 167 children >6 years old).

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