e-Journal – Issue 2011 Letter from the Editors Epilepsy and Anaesthesia Comparison of systemic hemodynamics after subarachnoid administration of either levobupivacaine or ropivacaine to elderly hypertensive patients Emerging issues on opioid treatment of chronic pain Known and unknown problems after prolonged use of opioids How to balance efficacy versus side effects of chronic opioid use When to start and when to terminate an opioid treatment