The objective of this study was to evaluate onset times and tracheal intubating conditions after administration of rocuronium or mivacurium in children of different ages. In this randomized double-blind study, 40 healthy (ASA I) children aged 1 to 14 years were studied. They were divided, according to age, into two groups: Group A (n=20) included patients 1 to 3 years of age and Group B (n=20) 4 to 14 years of age. After general anesthesia induction patients in both groups were further divided into two subgroups.
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A significant number of patients exhibit impairment in cognitive function immediately following surgery or later; the impact of this postoperative cognitive dysfunction on the recovery and quality of life of the patient but also on the necessity for supportive and rehabilitation care is important. Risk factors for postoperative cognitive impairment and postoperative delirium have been described and it is these groups of patients that require early identification and careful follow up to avoid complications in postoperative care.
Continue readingGeneral anaesthesia is associated with a reduction in heart rate variability (HRV) compared to awake situation. In this study the hypothesis of reduction in HRV was tested in two different levels of anaesthesia depth. Forty six patients were randomly allocated in two groups, where anaesthesia was maintained with sevoflurane (n=23) or propofol (n=23). Administration of both anaesthetics was regulated in order to achieve a BIS value 25±5, followed by an increase to 55±5, both being stable for 5 min.
Continue readingIn order to evaluate the postoperative analgesic effect of caudal administration of levobupivacaine, plain or in combination with neostigmine, 50 children who underwent medium gravity operations were studied. The children were randomly divided into two groups: Group L received 1 ml/kg of levobupivacaine 0.25% solution via caudal route, while in Group LN the same solution plus 2 μg/kg neostigmine was given.
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This study was undertaken to investigate the efficacy of prehydration with crystalloids or colloids for preventing spinal anaesthesia-induced hypotension in elderly normotensive and hypertensive patients. Eighty physical status ASA I-III elderly patients were enrolled in this study, receiving spinal anesthesia.
Continue readingAcute inflammatory response is the body’s direct response to noxious stimuli or to tissue necrosis. Ischemia-reperfusion lesion is a clinical state of acute inflammation with leucocyte-induced tissue damage. Ischemia promotes an inflammatory response which sensitizes tissues to further damage during reperfusion. Reperfusion activates inflammatory mediators from remote vascular or tissue sites or from the local vascular bed. Reperfusion remains the cornerstone for the repair of ischemic areas.
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Atropine has been used in the past as a premedication drug to decrease the sialorrhea of the second stage of anaesthesia and prevent bradycardia caused by the administration of succinylcholine, opiods or volatile anaesthetics. The purpose of this study is the investigation of the haemodynamic fluctuations during induction of anaesthesia and intubation of the trachea, in children and adults either premedicated or not with atropine.
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