opioids

Opioid analgesics are widely accepted as first-line treatment for moderate to severe cancer pain: while their use in patients with non-cancer pain syndromes has increased substantially over the last years. However, opioid analgesia produces numerous adverse effects. These effects have a negative impact on patient’s quality of life, may impair adherence to treatment and finally limitate opioid use.

Continue reading

Opioid use for cancer pain is well established in medical literature. Recommended by the european guidelines (European Society for Medical Oncology - ESMO, European Association for Palliative Care – EAPC), the World Health Organization (WHO) analgesic ladder remains the gold standard in cancer pain management.

Continue reading

The issue of cerebral circulation and oxygen delivery to the brain requires constant vigilance for the clinician in the ICU, the trauma unit and the neurosurgical operation suite. These patients are administered anaesthetic medications that affect cerebral physiology by a lot of different and some times unexplored mechanisms.

Continue reading

Cell protection against hypoxia can be mediated by brief periods of sublethal ischemia, a phenomenon called ‘preconditioning’. The molecular mechanisms that are responsible for cell protection are extremely complicated; however, extensive research in molecular biology and cellular physiology has uncovered many different signaling pathways, especially in cardiac tissues.

Continue reading
Language
Αναβάθμιση του Impact Factor

Archive
Επιλέξτε χρονιά
ATOM Feed
RSS Feed
RDF Feed
Creative Commons License